Dr. Yipeng Sui

Assistant Professor

Office: BHS 201E   |    Phone: (308) 865-8000   |    Email: suiy@sydotnet.net

Dr. Yipeng Sui

Biography

Area of Interest:

  • Cardiovascular disease
  • Obesity-related metabolic disorder

Degrees:

  • B.S. (2004) - Shaanxi Normal University, China
  • Ph.D. (2009) - Shandong University, China

 Professional Affiliations:

  • American Heart Association
  • Entomology Society of America

Dissertation:

Sui, Y.  2009.  Characterization and influences of classical insect hormones on the expression profiles of proteases and lipase from the cotton bollworm.  Ph.D. Dissertation, Shandong University. 

Publications:

  • Brown, C., Kariuki, W., Zhong, H.A., Kippes, A., and Sui, Y.  2024.  Cannabidiol promotes intestinal cholesterol uptake mediated by Pregnane X receptor.  Front Endocrinol (Lausanne) 15:1398462. PubMed Central PMCID: PMC11217338.
  • Sui, Y., Meng, Z., Chen, J., Liu, J., Hernandez, R., Gonzales, M.B., Gwag, T., Morris, A.J., and Zhou, C.  2021.  Effects of dicyclohexyl phthalate exposure on pxr activation and lipid homeostasis in mice.  Environmental Health Perspectives 129(12)  doi.org/10.1289/EHP9262
  • Sui, Y., Meng, Z., Park, S.H., Lu, W., Livelo, C., Chen, Q., Zhou, T., and Zhou, C.  2020.  Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice.  J Lipid Res doi:10.1194/jlr.RA119000122.  PMID: 32170024.
  • Hoffman, J., Petriello, M., Morris, A., Mottaleb, M., Sui, Y., Zhou, C., Deng, P., Wang, C., and Hennig, B.  2020.  Prebiotic inulin consumption reduces dioxin-like PCB 126-mediated hepatotoxicity and gut dysbiosis in hyperlipidemic Ldlr deficient mice.  Environ Pollut  doi:10.1016/j.envpol.2020.114183.  PMID: 32105967.
  • Meng, Z., Gwag, T., Sui, Y., Park, S.H., Zhou, X., and Zhou, C.  2019.  The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling.  JCI Insight 4(3). pii: 125657.  PMID: 30728326.
  • Gwag, T., Meng, Z., Sui, Y., Helsley, R.N., Park, S.H., Greenberg, R.N., and Zhou, C.  2019.  Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis in mice.  J Hepatology pii: S0168-8278(19)30029-7.  PMID: 30677459.
  • Sui, Y., Park, S.H., Wang, F., and Zhou, C.  2018.  Perinatal bisphenol A exposure increases atherosclerosis in adult male PXR-humanized mice.  Endocrinology 159: 1595-1608.  PMID: 29425287.
  • Sui, Y., Liu, Z., Park, S.H., Thatcher, S.E., Zhu, B., Fernandez, J.P., Molina, H., Kern, P.A., and Zhou, C.  2018.  IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation.  JCI Insight 3: e96660.  PMID: 29367460.
  • Wang, F., Liu, Z., Park, S.H., Gwag, T., Lu, W., Ma, M., Sui, Y., and Zhou, C.  2018.  Myeloid β-catenin deficiency exacerbates atherosclerosis in low-density lipoprotein receptor-deficient mice.  Arterioscler Thromb Vasc Biol 38: doi: 10.1161/ ATVBAHA.118.311059.  PMID: 29724817.
  • Helsley, R.N., Sui, Y., Park, S-H., Liu, Z., Lee, R.G., Zhu, B., Kern, P.A., and Zhou, C.  2016.  Targeting IκB kinase β in adipocyte lineage cells for treatment of obesity and metabolic dysfunctions.  Stem Cells 34:1883-1895.  PMID: 26991836.
  • Park, S-H., Liu, Z., Sui, Y., Helsley, R.N., Powell, D.K., Zhu, B., Kern, P.A., and Zhou, C.  2016.  IKKβ is essential for adipocyte survival and adaptive adipose remodeling in obesity.  Diabetes 65:1616-29.  PMID: 26993069.
  • Sui, Y.*, Helsley, R.N.*, Park, S.H., Song, X., Liu, Z., and Zhou, C.  2015.  Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia.  Mol Endocrinol 29:765-776.  (*Co-first authors).  PMID: 25811240.
  • Sui, Y., Park, S.H., Helsley, R.N., Sunkara, M., Gonzalez, F.J., Morris, A.J., and Zhou, C.  2014.  Bisphenol A increases atherosclerosis in pregnane X receptor-humanized ApoE deficient mice.  J Am Heart Assoc 3: e000492.  PMID: 24755147.
  • Sui, Y., Park, S.H., Xu, J., Monette, S., Helsley, R.N., Han, S.S., and Zhou, C.  2014.  IKKβ links vascular inflammation to obesity and atherosclerosis.  J Exp Med 211:869-886.  PMID: 24799533.
  • Cui, Y., Sui, Y., Xu, J., Zhu, F., and Palli, S.R.  2014.  Juvenile hormone regulates Aedes aegypti Krüppel homolog 1 through a conserved E box motif.  Insect Biochem Mol Biol 52:23-32.  PMID: 24931431.
  • Helsley, R.N.*, Sui, Y.*, Ai, N., Park, S.H., Welsh, W.J., and Zhou, C.  2013.  Pregnane X receptor mediates dyslipidemia induced by the HIV protease inhibitor amprenavir in mice.  Mol Pharmacol 83:1190-9.  (*Co-first authors).  PMID: 23519392.
  • Sui, Y., Ai, N., Park, S.H., Rios-Pilier, J., Perkins, J.T., Welsh, W.J., and Zhou, C.  2012.  Bisphenol A and its analogues activate human pregnane X receptor.  Environ Health Perspect 120:399-405.  PMID: 22214767.
  • Park, S.H., Sui, Y., Gizard, F., Xu, J., Rios-Pilier, J., Helsley, R.N., Han, S.S., and Zhou, C.  2012.  Myeloidspecific IκB kinase β deficiency decreases atherosclerosis in low-density lipoprotein receptor-deficient mice.  Arterioscler Thromb Vasc Biol 32:2869-2876.  PMID: 23023371.
  • Sui, Y., Xu, J., Rios-Pilier, J., and Zhou, C.  2011.  Deficiency of PXR decreases atherosclerosis in apoE deficient mice.  J Lipid Res 52:1652-1659.  PMID: 21685500.
  • Zhang, Z., Xu, J., Sheng, Z., Sui, Y., and Palli, S.R.  2011.  Steroid receptor co-activator is required for juvenile hormone signal transduction through a bHLH-PAS transcription factor, methoprene tolerant.  J Biol Chem 286:8437-47.  PMID: 21190938.
  • Sui, Y., Wang, J., and Zhao, X.  2009.  The impacts of classical insect hormones on the expression profiles of a new digestive trypsin-like protease (TLP) from the cotton bollworm, Helicoverpa armigera.  Insect Mol Biol 18:443–452.  PMID: 19469806.
  • Sui, Y., Liu, X., Chai, L., Wang, J., and Zhao, X.  2009.  Characterization and influences of classical insect hormones on the expression profiles of a molting carboxypeptidase A from the cotton bollworm (Helicoverpa armigera).  Insect Mol Biol 18:353–363.  PMID: 19523067.
  • Liu, Y., Sui, Y., Wang, J., and Zhao, X.  2009.  Characterization of the trypsin-like protease (Ha-TLP2) constitutively expressed in the integument of the cotton bollworm, Helicoverpa armigera.  Arch Insect Biochem Physiol 72:74-87.  PMID: 19557747.
  • Sui, Y., Wang, J., and Zhao, X.  2008.  Effects of classical insect hormones on the expression profiles of a lipase gene from the cotton bollworm (Helicoverpa armigera).  Insect Mol Biol 17:523–529. PMID:18828838.